What condition is characterized by gastrinomas secreting excess gastrin?

The condition characterized by gastrinomas secreting excess gastrin is Zollinger-Ellison Syndrome. Gastrinomas are tumor cells, often found in the pancreas or duodenum, that produce high levels of gastrin, a hormone that stimulates gastric acid secretion. The excessive gastrin leads to increased acid production in the stomach, causing severe gastric hypersecretion.

Individuals with Zollinger-Ellison Syndrome frequently experience symptoms such as recurrent peptic ulcers, which result from the high acidity in the stomach and small intestine. This syndrome is a classic example of a gastrin-secreting tumor, distinguishing it from other gastrointestinal conditions.

The other options refer to different gastrointestinal disorders that may involve acid secretion and digestive symptoms but are not directly associated with the primary cause of elevated gastrin levels as seen in Zollinger-Ellison Syndrome. For instance, peptic ulcer disease can occur as a consequence of the high gastrin levels but does not itself cause the gastrinomas. Similarly, gastroesophageal reflux disease and achlorhydria are related to acid regulation and secretion, but they do not typically involve the excess gastrin secreted by gastrinomas.