What do S cells in the pancreas primarily increase?

S cells in the pancreas primarily increase bicarbonate secretion. These cells are located in the pancreatic ducts and play a crucial role in the digestive process by producing secretin, a hormone that stimulates the pancreas to release bicarbonate into the small intestine. Bicarbonate serves to neutralize gastric acid from the stomach, creating a more alkaline environment that is necessary for optimal enzyme activity during digestion.

This regulatory mechanism is vital for the proper functioning of the digestive system, as it prevents damage to the intestinal lining and allows digestive enzymes to work effectively. The secretion of bicarbonate is essential for maintaining pH balance in the small intestine, thereby facilitating better digestion and nutrient absorption.