What is a common cause of gastric ulcers?

A defective mucosal barrier is a recognized common cause of gastric ulcers. The gastric lining is protected by mucus, which serves as a barrier against the harsh acidic environment of the stomach. When this mucosal barrier is compromised, whether due to long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), excessive alcohol consumption, or infection by Helicobacter pylori, it can lead to damage of the stomach lining and result in the formation of ulcers. The erosion of the protective layer allows stomach acid to irritate the tissue beneath, leading to ulceration.

Other factors listed, such as persistent nausea, excessive exercise, and food allergies, do not directly contribute to the development of gastric ulcers to the same extent. While they may cause discomfort or digestive issues, they are not primary factors in the pathophysiology of gastric ulcer formation. Understanding the role of the mucosal barrier is essential in grasping how gastric ulcers can develop and the importance of maintaining its integrity for digestive health.