Which factor might influence the onset of hypertrophic pyloric stenosis?

A family history of hypertrophic pyloric stenosis is known to be a significant risk factor for the condition. This surgical condition, which affects infants, is characterized by the narrowing of the pylorus, the opening between the stomach and the small intestine. Genetic predisposition plays a crucial role, as the condition tends to occur more frequently in families with a history of hypertrophic pyloric stenosis. This suggests that certain genetic factors may increase susceptibility to developing the condition.

Other potential factors that have been studied include maternal smoking habits, infant age, and low birth weight. However, while they may influence infant health, they are not as directly linked to the risk of hypertrophic pyloric stenosis as a family history of the condition. Thus, having a family history remains the most clearly defined risk factor for the onset of this disorder.