Which sympathetic nerve is involved in the innervation of the liver?

The greater splanchnic nerve plays a significant role in the sympathetic innervation of the liver. This nerve arises from the thoracic sympathetic ganglia (specifically from T5 to T9) and carries preganglionic sympathetic fibers to the celiac ganglion. Once they reach this ganglion, the fibers synapse with postganglionic neurons that innervate several abdominal organs, including the liver.

In terms of its function, the sympathetic stimulation from the greater splanchnic nerve is involved in processes such as the regulation of blood glucose levels and the management of blood flow to the liver, which are crucial for stress-related responses. By activating the liver's glycogenolysis and gluconeogenesis, the sympathetic nervous system helps provide energy to the body during stressful situations. Thus, the greater splanchnic nerve is essential for the proper sympathetic control of liver activities.